M5207 - Developmental Neurobiology
Teile
M5207A: "Developmental Neurobiology - Concepts and Methods"
1 SWS, 1 CP
M5207B: " Developmental Neurobiology - Concepts and Methods "
6 SWS, 7 CP
Lehrende
Prof. Dr. Martin Bastmeyer, Dr. Joachim Bentrop, Dr. S. Scholpp, Dr. Franco Weth
Leistungsnachweis
Klausur zu den Inhalten der Vorlesung (M5207A) und des Praktikums (M5207B). Leistungen aus dem Praktikum (Protokoll, Ergebnispräsentation) gehen in Form von Bonuspunkten mit bis zu 10 % in das Klausurergebnis mit ein. Anmeldung zur Klausur derzeit noch Anmeldeformular am Klausurtag, langfristig elektronisch über das elektronische Vorlesungsverzeichnis.
Anrechenbarkeit
Masterfächer: Zoologie, Entwicklungsbiologie, Zellbiologie, Biophysik
Andere Studiengänge: Biologie Lehramt (LA7), Chemische Biologie
Anmeldung
Anmeldung über die Modulwahl und Studienportal
(Prüfungsnummer 271+272, als F3-Praktkum 631)
Organisation und Inhalte
M5207A: Developmental Neurobiology - Concepts and Methods (Vorlesung)
Zeit: 1. Block im Wintersemester, nach Vereinbarung
Ort: MRI (Haid-und-Neu-Str. 9), Raum nach Absprache
Lehrmethoden: Vorlesung 100%
Lernziel / Goal:
Goal is to acquire an understanding of current concepts and methods in neurobiology focussing on axonal growth and guidance.
Lerninhalte / Contents:
The course introduces methods and concepts of modern animal neurobiology.
Topics include:
- molecular composition, structure and function of the vertebrate nervous system
- axonal outgrowth and pathfinding
- neurodevelopment and regeneration
- model systems: cell culture, zebrafish, mouse
- fluorescence microscopy and image analysis
M5207B: Developmental Neurobiology (Praktikum)
Zeit / Time: 1. Block im Wintersemester, Mo.-Fr. nach Absprache
Ort / Place: MRI (Haid-und-Neu-Str. 9), Labore der Abt. Zell- und Neurobiologie
Lehrmethoden / Methods: Praktikum 90%, Abschlussseminar mit Präsentation der Versuche 10 %
Lernziel / Goal:
Goal is to acquire familiarity with current concepts and methodology as well as design and conception of scientific projects. Furthermore, competence in scientific documentation and presentation of scientific results shall be achieved..
Lerninhalte / Contents:
Students conduct small research projects on neurobiological topics in the context of current research. They write up a report on their projects and present their results at the end of the block. A high degree of self-responsibility and self-organization is expected.
Topics include:
- zebrafish and mouse neurodevelopment
- RNA antisense technologies, manipulation of protein expression
- establishment of neuronal cell cultures
- retinal explants
- biofunctionalization of surfaces
- In-situ hybridisation, molecular cloning, qPCR
- immunostaining, digital fluorescence microscopy, quantitative image analysis
Research topics in Molecular Cell and Neurobiology
http://www.zi1.uni-karlsruhe.de/forschung.php
Lernhilfen / Literature:
- Skript zur Vorlesung
- Brown, Keynes, Lumsden: The developing brain
- Sanes, Reh, Harris: Development of the nervous system
- Purves et al.: Neuroscience
- Alberts et al.: Molecular Biology of the Cell
- Lodish et al.: Molecular Cell Biology
- Karp: Molekulare Zellbiologie
- Pollard; Cell Biology